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Generalized Anxiety Disorder
Buspar (generic Buspirone)
Buspirone Hydrochloride is indicated
for the management of anxiety disorder or the short-term relief of the
symptoms of anxiety. Buspar is an agent that is not chemically or
pharmacologically related to the benzodiazepines (e.g. Valium, Xanax)
barbituates, or other sedative/anti-anxiety drugs.
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Generalized Anxiety Disorder Medications
Generic Buspar Information
HOW DOES BUSPIRONE FOR ANXIETY DISORDER WORK?
The mechanism of action of BUSPAR (for generalized anxiety disorder) is not clearly
known. BUSPAR differs from typical benzodiazepines like Vallium or Xanax
anti-anxiety medication in that it does not exert anti-seizure or muscle
relaxant effects. It also lacks the prominent sedative effect that is
associated with benzodiazepines
In vitro studies have shown that Buspar for generalized anxiety disorder
has a high affinity for
serotonin receptors (receptors in the brain that mediate arousal).
BUSPAR has no significant affinity for benzodiazepine receptors in the brain.
HOW EFFECTIVE IS BUSPAR FOR GENERALIZED ANXIETY DISORDER?
The excellent efficacy of BUSPAR has been
demonstrated in controlled clinical trials of outpatients with a diagnosis
of Generalized Anxiety Disorder (GAD).
The patients evaluated in these studies had
experienced symptoms for periods of 1 month to over 1 year prior to the
study, with an average symptom duration of 6 months. Generalized,
persistent anxiety (of at least one month continual duration), manifested
by symptoms from three of the four following categories:
Motor tension:
Shakiness, jitteriness, jumpiness, trembling, tension, muscle aches,
fatigability, inability to relax, eyelid twitch, furrowed brow, strained
face, fidgeting, restlessness, easy startle.
Autonomic hyperactivity: Sweating, heart pounding or racing, cold, clammy hands, dry
mouth, dizziness, lightheadedness, paresthesias (tingling in hands or
feet), upset stomach, hot or cold spells, frequent urination, diarrhea,
discomfort in the pit of the stomach, lump in the throat, flushing,
pallor, high resting pulse and respiration rate.
Apprehensive expectation: Anxiety, worry, fear, rumination, and
anticipation of misfortune to self or others.
Vigilance and scanning:
Hyper-attentiveness resulting in distractibility, difficulty
in concentrating, insomnia, feeling "on edge", irritability, impatience.
The effectiveness of BUSPAR in long-term use, that
is, for more than 3 to 4 weeks, has not been demonstrated in controlled
trials. There is no body of evidence available that systematically
addresses the appropriate duration of treatment for GAD. However, in a
study of long-term use, 264 patients were treated with BUSPAR for 1 year
without ill effect. Therefore, the physician who elects to use BUSPAR for
extended periods should periodically reassess the usefulness of the drug
for the individual patient.
DOSAGE AND ADMINISTRATION:
The recommended initial dose is 15 mg daily (5 mg 3 times a day). To
achieve an optimal therapeutic response, at intervals of 2 to 3 days the
dosage may be increased 5 mg per day, as needed. The maximum daily dosage
should not exceed 60 mg per day. In clinical trials allowing dose
titration, divided doses of 20 to 30 mg per day were commonly
employed.
ADVERSE REACTIONS
The more commonly observed untoward events
associated with the use of BUSPAR not seen at an equivalent incidence
among placebo-treated patients include dizziness, nausea, headache,
nervousness, lightheadedness, and excitement.
Other common adverse events included: central
nervous system disturbances (3.4%), primarily dizziness, insomnia,
nervousness, drowsiness, and lightheaded feeling; gastrointestinal
disturbances (1.2%), primarily nausea; and miscellaneous disturbances
(1.1%), primarily headache and fatigue.
Interference with cognitive and motor performance:
Studies indicate that BUSPAR is less sedating than other anti-anxiety
medications and that it does not produce significant functional
impairment. However, its CNS effects in any individual patient may not be
predictable.
Therefore, patients should be cautioned about
operating an automobile or using complex machinery until they are
reasonably certain that BUSPAR treatment does not affect them
adversely.
While formal studies of the interaction of BUSPAR
with alcohol indicate that BUSPAR does not increase alcohol-induced
impairment in motor and mental performance, it is prudent to avoid
concomitant use of alcohol and BUSPAR.
DRUG ABUSE AND DEPENDENCE:
In human and animal studies, BUSPAR has shown no
potential for abuse or diversion and there is no evidence that it causes
tolerance, or either physical or psychological dependence. Human
volunteers with a history of recreational drug or alcohol usage were
studied in two double-blind clinical investigations. None of the subjects
were able to distinguish between BUSPAR and placebo. In addition, studies
in monkeys, mice, and rats have indicated that BUSPAR lacks potential for
abuse.
Although there is no direct evidence that BUSPAR
causes physical dependence or drug-seeking behavior, it is difficult to
predict from experiments the extent to which a CNS-active drug will be misused.
BE SURE TO INCLUDE IN YOUR PHYSCIAL EXAMINATION/MEDICAL QUESTIONAIRRE
FORM THE FOLLOWING INFORMATION:
Include any medications, prescription or non-prescription, alcohol,
or drugs that you are now taking or plan to take during your treatment with BUSPAR.
Note if you are pregnant, or if you are planning to
become pregnant while you are taking BUSPAR.
Note if you are breast-feeding an infant.
ADDITIONAL QUESTIONS:
Not every question can be addressed in this FAQ page.
If any additional questions remain we suggest you contact your local physician or email us at
patientinfo@1-Xenical.com.
At CoralCalcium-Supplements.com, we do all that we can to insure your safety.
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